Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes |
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Authors: | Jesú s Casas |
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Affiliation: | Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, Sweden |
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Abstract: | Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes with formaldehyde has been developed, which furnished the corresponding α-hydroxymethylated adducts with high chemo- and enantioselectivity. The reaction is catalyzed by proline derivatives and is a simple method for the enantioselective synthesis of α-hydroxymethylated ketones and aldehydes, and C-2 symmetric diols. |
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Keywords: | α-Hydroxymethylation Organocatalysis Ketones Aldehydes Asymmetric |
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