Highly stereoselective addition of silylphosphines to chiral aldehydes |
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| Authors: | Oleg I. Kolodiazhnyi |
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| Affiliation: | Institute of Bioorganic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street, 1, Kiev, Ukraine |
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| Abstract: | The reaction between diphenyl(trimethylsilyl)phosphine and chiral aldehydes proceeds with high stereoselectivity to give diastereomerically pure tertiary α-trimethylsiloxyalkylphosphines. The diastereomeric purity of the addition products was 90-100%. The products were purified via the formation of borane-phosphine complexes. The reaction of bis(trimethylsilyl)phenylphosphine with acetonide (R)-glyceraldehyde provides tertiary bis(glyceryl)phosphines. |
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| Keywords: | Stereoselectivity Silylphosphines Chiral aldehydes Chiral α-trimethylsiloxyalkylphosphines |
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