Oxazolidine-2-thiones: a molecular modeling study |
| |
| Authors: | Neha Gandhi |
| |
| Affiliation: | Department of Chemistry, Zydus Research Centre, Cadila Healthcare Ltd, Sarkhej-Bavla N. H.8A, Moraiya, Ahmedabad 382210, India |
| |
| Abstract: | Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding. |
| |
| Keywords: | Oxazolidine-2-thiones Linezolid Molecular modeling 23S rRNA Antibacterial Piecewise linear potential (PLP) Thioacetamide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
