Synthesis of (+)- and (−)-isocarvone |
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| Authors: | Miguel A González |
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| Institution: | Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA |
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| Abstract: | The first synthesis of 5-isopropenyl-3-methyl-cyclohex-2-enone, (isocarvone) (2), in enantiomerically pure form is reported. Both enantiomers of 2 can be produced by manipulation of carboxylic acid 5, which is available from R-(−)-carvone (1). These materials provide new chiral building blocks that could be used in total synthesis of natural products and related optically active compounds. |
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| Keywords: | Terpenes Natural products Synthetic methods Chiral synthon |
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