Dual linker with a reference cleavage site for information rich analysis of polymer-supported transformations |
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Authors: | Viktor Krchňák Greg A Slough |
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Institution: | a Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, IN 46556, USA b Chemistry Department, Kalamazoo College, 1200 Academy St., Kalamazoo, MI 49006, USA |
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Abstract: | Two dual linker systems with specific reference cleavage sites were designed and synthesized to accelerate and simplify development and optimization of reaction conditions for solid-phase synthesis. The dual linker allows simple evaluation of cleavage rate of polymer-supported compounds from the linker and, at the same time, ensures that all resin-bound components are cleaved from the solid support. The dual linker 4 was assembled from two Wang linkers connected by a three carbon spacer. The linker 9 was synthesized using the PAL and HMPB linkers. |
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Keywords: | Solid-phase synthesis Dual linker Cleavage rate |
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