Ugi multicomponent reaction with hydroxylamines: an efficient route to hydroxamic acid derivatives |
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| Authors: | Andrea Basso Renata Riva |
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| Institution: | Università degli Studi di Genova, Dipartimento di Chimica e Chimica Industriale, via Dodecaneso 31, 16146 Genova, Italy |
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| Abstract: | Ugi condensations with O-protected hydroxylamines have been successfully performed in THF using ZnCl2 as activating agent. This synthetic strategy opens up the route to a very convergent assemblage of `internal' hydroxamic acid derivatives (N-acyl-N-hydroxypeptides). |
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| Keywords: | Ugi multicomponent reaction Hydroxamic acids Hydroxylamines Metalloprotease inhibitors |
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