Asymmetric addition of KCN and Ac2O to aldehydes catalyzed by recyclable polymeric salen-Ti(IV) complexes |
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Authors: | Wei Huang |
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Institution: | Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, PR China |
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Abstract: | Polymeric salen-Ti(IV) complexes were employed in the enantioselective O-acetyl cyanation of aldehydes with KCN and Ac2O. The polymeric catalysts with appropriate crosslinking degree exhibited good activities and enantioselectivities, up to 94% yield and 91% ee were obtained at −20 °C with 1 mol % of catalyst (based on bimetallic catalytic unit). Moreover, the crosslinked polymeric catalyst could be easily recovered and reused for six consecutive runs without obvious decrease in activity and enantioselectivity. |
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Keywords: | O-Acetyl cyanohydrins Recyclable polymeric salen-Ti(IV) complexes Potassium cyanide Aldehyde Asymmetric cyanation |
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