Intramolecular cyclization reactions of aziridines with π-nucleophiles |
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| Authors: | Stephen C. Bergmeier Steven J. Katz Junfeng Huang Howard McPherson Patrick J. Donoghue Damon D. Reed |
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| Affiliation: | Department of Chemistry and Biochemistry, Ohio University, Clippinger Hall, Athens, OH 45701, USA |
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| Abstract: | We have found that aziridines will react with a variety of π-nucleophiles in intramolecular cyclization reactions to produce nitrogen containing core structures found in a variety of bioactive molecules. These cyclizations are more general and facile than corresponding intermolecular reactions. We have examined the effects of ring size, π-nucleophile identity and substitution on this reaction. |
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| Keywords: | Aziridines Amines Bicyclic heterocyclic compounds |
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