Synthesis of arylacetic acid derivatives from diethyl malonate using in situ formed palladium(1,3-dialkylimidazolidin-2-ylidene) catalysts |
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| Authors: | Ismail Özdemir Engin Çetinkaya |
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| Institution: | a Department of Chemistry, Inönü University, 44069 Malatya, Turkey
b Department of Chemistry, Ege University, Bornova, 35100 Izmir, Turkey |
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| Abstract: | The in situ prepared three component system Pd(OAc)2/1,3-bis(alkyl) imidazolinium halide LHX (1-5)/Cs2CO3 catalyses the arylation of diethyl malonate efficiently with accompanying dealkoxycarbonylation. Imidazolinium salts with bulky benzyl and alkoxyethyl groups were found to be the most efficient and afforded α-arylacetates in high yields when employing a wide variety of substrates. |
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| Keywords: | Arylations Palladium catalysts NHC complexes Diethyl malonate |
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