RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A) |
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| Authors: | Narendra K Tripathy |
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| Institution: | Department of Medicinal Chemistry, 1251 Wescoe Hall Drive, University of Kansas, Lawrence, KS 66045-7582, USA |
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| Abstract: | An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction. |
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| Keywords: | Cryptophycins Antitumor agents Total synthesis RCM |
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