Regio- and stereoselective ring opening of vinyl epoxides with MgBr2 |
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| Authors: | Jae Du Ha Sun Young Kim Su Jung Lee Seung Kyu Kang Jin Hee Ahn Sung Soo Kim Joong-Kwon Choi |
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| Institution: | Medicinal Science Division, Korea Research Institute of Chemical Technology, Taejon 305-600, South Korea |
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| Abstract: | The regio- and stereoselective ring opening of vinyl epoxides has been achieved by the use of Lewis acid, MgBr2, affording bromohydrins in excellent yield, which are readily transformed to azidoalcohol, a key intermediate of several classes of pyrrolizidine and indolizidine alkaloids. The scope and limitations of the reaction are discussed. |
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| Keywords: | Vinyl epoxide Ring opening Bromohydrin MgBr2 |
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