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Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent |
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| Authors: | James A Wilkinson Steven B Rossington Nigel Hussain |
| Institution: | a Centre for Drug Design, Biosciences Research Institute, Cockcroft Building, University of Salford, Salford M5 4WT, UK b AstraZeneca Process R+D, Silk Road, Cheshire, Macclesfield SK10 2NG, UK c GlaxoSmithKline Chemical Development, Old Powder Mills, Kent, Tonbridge TN11 9AN, UK |
| Abstract: | Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimethylsilylation have all been carried out with acceptable ee. |
| Keywords: | Asymmetric Alkylation Diarylmethane Sparteine |
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