Use of highly reactive, versatile and air-stable palladium-phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst for the optimized Suzuki-Miyaura cross-coupling of less reactive heteroaryl chlorides and arylboronic acids |
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| Authors: | Subhash P. Khanapure David S. Garvey |
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| Affiliation: | NitroMed, Inc., Department of Chemistry, 12 Oak Park Drive, Bedford, MA 01730, USA |
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| Abstract: | Using highly reactive air-stable palladium-phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst, synthesis of heteroaryl-aryl cross-coupled products via palladium-catalyzed Suzuki-Miyaura coupling of less reactive substituted 3-chloropyridines with arylboronic acids was achieved in high yields. |
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| Keywords: | Suzuki-Miyamura 3-Chloropyridines Arylboronic acids POPd Cyclooxygenase |
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