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Solid-phase synthesis of amidines by the reduction of amidoximes |
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| Authors: | Jo?ko Cesar Kristina Nadrah Marija Sollner Dolenc |
| Institution: | Faculty of Pharmacy, University of Ljubljana, Ašker?eva 7, 1000 Ljubljana, Slovenia |
| Abstract: | Amidines can be prepared on a solid support by reducing polymer-bound amidoximes with SnCl2·2H2O. The method has proved to be straightforward and highly efficient. Amidoximes attached to the solid support are readily available by treating resin-bound nitriles with hydroxylamine. |
| Keywords: | Solid-phase synthesis Amidines Amidoximes Tin(II) chloride Reduction |
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