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Synthesis and properties of a pyrrole-imidazole polyamide having a ferrocene dicarboxylic amide linker |
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| Authors: | Kohji Seio Masahiro Mizuta Takeshi Terada |
| Institution: | a Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan b Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan c CREST, JST (Japan Science and Technology Agency), 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan |
| Abstract: | A new minor groove binder 1 having a redox active ferrocene dicarboxamide linker was synthesized. The affinity of the newly synthesized compound to the target DNA was confirmed by CD titration experiments. Moreover, the redox property of 1 was also demonstrated by cyclic voltammetry. These results suggest the potential of 1 as a new tool for electrochemical gene detection technology. |
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