A practical synthesis of carbamates using an ‘in-situ’ generated polymer-supported chloroformate |
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| Authors: | David Mormeneo Amadeu Llebaria |
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| Affiliation: | a Universidad de Barcelona, Facultad de Farmacia, Undad de Química Farmacéutica (Unidad Asociada al CSIC), Avda. Juan XXIII, s/n, 08028 Barcelona, Spain
b Research Unit on Bioactive Molecules (RUBAM), Departament de Química Orgànica Biològica, Institut d’Investigacions Químiques i Ambientals de Barcelona (IIQABC.S.I.C), Jordi Girona 18-26, 08034 Barcelona, Spain |
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| Abstract: | A versatile method for the synthesis of carbamates from an ‘in-situ’ generated polymer-supported chloroformate resin is presented. BTC (bis-trichloromethyl carbonate) is used as phosgene equivalent to afford a supported chloroformate, which, by sequential ‘one-pot’ reaction with a variety of alcohols and amines, furnishes the corresponding carbamates in high yields and purities. |
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| Keywords: | Supported reagents Solid phase Carbamates Phosgene equivalent Parallel synthesis |
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