Phosphonyl radical addition to enol ethers. The stereoselective synthesis of cyclic ethers |
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| Authors: | Christopher M Jessop Anne Routledge |
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| Institution: | a Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
b Uniqema, Wilton Centre, Wilton, Redcar TS10 4RF, UK |
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| Abstract: | Addition of diethyl phosphite or diethyl thiophosphite to enol ethers, in the presence of a radical initiator, results in the regioselective synthesis of organophosphonate or phosphonothioate derivatives, respectively, under mild conditions. This method can be applied to the stereoselective formation of substituted tetrahydrofurans and tetrahydropyrans, on cyclisation of vinyl ethers bearing unsaturated side chains. |
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| Keywords: | Cyclisation Phosphorus compounds Radicals and radical reactions |
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