|
|||||
|
|
Formal total synthesis of camptothecin via ring-closing metathesis strategy |
|
| Authors: | Subhash P. Chavan K. Pasupathy M.S. Venkatraman Ramesh R. Kale |
| Affiliation: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India |
| Abstract: | A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the dihydropyridone 3. |
| Keywords: | Anticancer Camptothecin Ring-closing metathesis (RCM) Pyridone |
| 本文献已被 ScienceDirect 等数据库收录！ | |