A flexible approach for the synthesis of selectively labelled l-arginine |
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Authors: | Deborah J Hamilton |
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Institution: | Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK |
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Abstract: | A simple and efficient synthesis of l-arginine has been achieved in 12 steps and 24% overall yield. Regioselective reduction and functional group manipulation of the β-side chain of aspartic acid allowed the preparation of an ornithine derivative, which was then guanylated with a bis-protected 1-guanyl-pyrazole and deprotected to give l-arginine. This approach allows the flexible incorporation of stable isotopes and this is demonstrated using potassium 13C-cyanide, which has resulted in the preparation of 5-13C-l-arginine. |
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Keywords: | l-Arginine" target="_blank">l-Arginine Stable isotopes Stereospecific synthesis Guanylation |
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