a School of Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, UK b AstraZeneca Charnwood, Department of Medicinal Chemistry, Bakewell Road, Loughborough, Leics, LE11 5RH, UK
Abstract:
The palladium catalysed insertion of isonitriles into aryl bromides carrying pendant amine or alcohol groups on the ortho position affords cyclic amidines or imidates in good yield.