A new and convenient in-situ method of generating phenyl isocyanates from anilines using oxalyl chloride |
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| Authors: | Lynette M Oh PGrant Spoors Richard M Goodman |
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| Institution: | Synthetic Chemistry, Chemical Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA |
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| Abstract: | A new and convenient method of generating phenyl isocyanates from anilines using oxalyl chloride is described. Acylation of a variety of substituted aniline hydrochlorides with oxalyl chloride affords the intermediate oxamic chlorides, which smoothly undergo thermal decomposition to the corresponding isocyanates. |
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| Keywords: | Phenyl isocyanates Anilines Oxalyl chloride |
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