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Enantioselective synthesis of 1-deoxy-d-gulonojirimycin from a phenylglycinol-derived lactam |
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| Authors: | Mercedes Amat Marta Huguet Oriol Bassas Joan Bosch Josefa Badia Juan Aguilar |
| Institution: | a Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain b Department of Biochemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain |
| Abstract: | Cyclocondensation of (R)-phenylglycinol with appropriately γ-substituted δ-oxo acid derivatives provides bicyclic lactams from which the enantioselective synthesis of 1-deoxy-d-gulonojirimycin has been reported. |
| Keywords: | Azasugars Phenylglycinol Chiral bicyclic lactams Polyhydroxypiperidines Enantioselective synthesis |
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