|
|||||
|
|
First total synthesis of (+)-viroallosecurinine |
|
| Authors: | Toshio Honda Hidenori Namiki Masayuki Watanabe Hirotake Mizutani |
| Affiliation: | Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142-8501, Japan |
| Abstract: | The first diastereoselective chiral synthesis of (+)-viroallosecurinine, isolated from Securinega virosa as a cytotoxic alkaloid, was achieved by using a chelation-controlled addition of an alkyne moiety to the corresponding ketone, and a ring-closing metathesis, as key reactions. |
| Keywords: | (+)-Viroallosecurinine Ring closing-metathesis Chelation-controlled addition Securinega alkaloid Diastereoselective total synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |