Modified reaction conditions to achieve high regioselectivity in the two component synthesis of 1,5-diarylpyrazoles |
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| Authors: | Sunil K Singh M Srinivasa Reddy D Kavitha J Moses Babu Y Koteswar Rao |
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| Institution: | a Discovery Chemistry, Discovery Research--Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, India
b Analytical Division, Discovery Research--Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, India |
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| Abstract: | The factors affecting regioselectivity during the formation of 1,5-diarylpyrazoles from aryl hydrazines and 1,3-diketones are identified and the regioisomers were characterized by 1D NOESY, LC-NMR and X-ray analyses. A simple alteration in the usual reaction conditions is reported, which allows the exclusive formation of 1,5-diarylpyrazoles. |
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| Keywords: | Regioselectivity 1 5-Diarylpyrazoles 1D NOESY LC-NMR |
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