Structural determination of mannopeptimycin cyclic acetals |
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| Authors: | Haiyin He Ting-Zhong Wang Xidong Feng Joseph S Ashcroft Guy T Carter |
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| Institution: | a Department of Structural and Natural Products Chemistry, Chemical and Screening Sciences, Wyeth, Pearl River, NY 10965, USA
b Department of Medicinal Chemistry, Chemical and Screening Sciences, Wyeth, Pearl River, NY 10965, USA |
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| Abstract: | In structure-activity relationship (SAR) studies on mannopeptimycin antibiotics, mannopeptimycin α(1) was acetalized by reacting with certain dialkyl acetals under acidic conditions. The major products of these reactions were determined to be cyclic acetals at the 4,6-positions of the terminal mannose (Man-B), by exemplary spectroscopic analyses of two typical acetalization products 2 and 3. |
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