Synthesis of aminopyridines from 2-fluoropyridine and lithium amides |
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| Authors: | Lubov Pasumansky Soya Gamsey Bakthan Singaram |
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| Institution: | a Department of Chemistry and Biochemistry, University of California--Santa Cruz, Santa Cruz, CA 95064, USA
b Dowpharma, The Dow Chemical Company, Midland, MI 48674, USA |
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| Abstract: | Lithium amides promote the amination of 2-fluoropyridine under mild reaction conditions, providing 2-aminopyridines in good yields and purity. Treatment of 2-fluoropyridine with 1 equiv of lithium amide at room temperature affords complete conversion after 2 h. To our knowledge, this is the first study of lithium amide-promoted amination of fluoropyridines that are not further activated by electron-withdrawing groups. |
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| Keywords: | Aminopyridines 2-Fluoropyridine Lithium amides |
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