Solvents inducing oxidation of hydroxylamines |
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| Authors: | Horiyama Shizuyo Suwa Kiyoko Yamaki Masae Kataoka Hiromi Katagi Toyoshi Takayama Mitsuo Takeuchi Takae |
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| Institution: | Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan. horiyama@mwu.mukogawa-u.ac.jp |
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| Abstract: | Hydroxylamines gradually undergo oxidation to their oximes on being dissolved in organic solvent (e.g. methanol). This phenomenon was followed by (1)H-NMR and liquid chromatography-mass spectrometry (LC-MS). The oxidation rate was estimated from the peak area observed on the mass chromatogram at the protonated molecule or fragment ion on LC-atmospheric pressure chemical ionization (APCI)-MS. The results showed that the oxidation rate of hydroxylamines depended on the solvent type. |
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