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N0期鼻咽癌颈部放射治疗不同方法的比较
引用本文:郭凯平,何燕,邓超,马芳,邹文.N0期鼻咽癌颈部放射治疗不同方法的比较[J].暨南大学学报,2006,27(2):275-278.
作者姓名:郭凯平  何燕  邓超  马芳  邹文
作者单位:中南大学湘雅二医院肿瘤科,湖南,长沙,410011;中南大学湘雅二医院肿瘤科,湖南,长沙,410011;中南大学湘雅二医院肿瘤科,湖南,长沙,410011;中南大学湘雅二医院肿瘤科,湖南,长沙,410011;中南大学湘雅二医院肿瘤科,湖南,长沙,410011
摘    要:目的分析和比较鼻咽癌上颈部预防照射和全颈部预防照射的颈部复发率和生存率的差异,以探讨N0期鼻咽癌颈部放疗的范围.方法选取156例经病理组织学确诊的N0期鼻咽癌患者,其中80例接受上颈预防照射(上颈照射组),76例接受全颈预防照射(全颈照射组).用Kaplan-Meier和log-rank法计算和比较两组的生存率.结果上颈照射组和全颈照射组的1、3、5年生存率分别是98.7%、90.7%、81.3%和97.3%、85.1%、78.4%(P>0.05),1、3、5年无瘤生存率分别是89.3%、82.7%、72.0%和87.8%、79.7%、68.9%(P>0.05),颈部复发率分别是5.0%和3.9%,两组比较差异无显著性(P>0.05).结论对于颈淋巴结阴性的鼻咽癌患者只需作上颈部预防性照射.

关 键 词:鼻咽癌  放射治疗  预后
文章编号:1000-9965(2006)02-0275-04
修稿时间:2005年9月9日

Radiotherapy on neck for nasopharyngeal carcinoma patients with negative cervical lymph node
GUO Kai-ping,HE Yan,DENG Chao,MA Fang,ZHOU Wen.Radiotherapy on neck for nasopharyngeal carcinoma patients with negative cervical lymph node[J].Journal of Jinan University(Natural Science & Medicine Edition),2006,27(2):275-278.
Authors:GUO Kai-ping  HE Yan  DENG Chao  MA Fang  ZHOU Wen
Abstract:Aim: Nasopharyngeal carcinoma(NPC) patients with negative cervical lymph node(N_0-NPC) account for 30% or more of all NPC patients.Prophylactic irradiation to the upper neck is a criterion of treatment for these patients.This study was to analyze and compare long-term outcomes of the N_0-NPC patients treated by prophylactic irradiation to the upper neck and to the whole neck,and explore radiotherapy on neck for N_0-NPC patients.Methods: A total of 156 N_0-NPC patients proved by pathology,were treated in our department from Feb.1998 to Aug.2000.Of the 156 patients,80 received prophylactic irradiation to the upper neck(upper neck group),other 76 to the whole neck(whole neck group).Kaplan-Meier method and log-rank test were used to analyze and compare survival rate of the 2 groups.Results: The 1-,3-,5-year over survival rates were 98.7%,90.7%,81.3% in upper neck groups,and 97.3 %,85.1%,78.4% in whole neck groups(P>0.05).The 1-,3-,5-year disease-free survival rates were 89.3%, 82.7%,72.0% in upper neck group,and 87.8%,79.7%,68.9% in whole neck group(P>0.05).The incidence of cervical lymph nodes recurrence was 5.0 % in upper neck group,and 3.9% in whole neck group(P>0.05).Conclusion: Prophylactic irradiation to upper neck is recommended for N_0-NPC patients.
Keywords:nasopharyngeal carcinoma  radiotherapy  prognosis  
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