Synthesis and structural characterisation as 12-helix of the hexamer of a beta-amino acid tethered to a pyrrolidin-2-one ring |
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| Authors: | Menegazzo Ileana Fries Alexander Mammi Stefano Galeazzi Roberta Martelli Gianluca Orena Mario Rinaldi Samuele |
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| Affiliation: | Dipartimento di Scienze Chimiche, Università di Padova, ICB-CNR, Via Marzolo 1, I-35131 Padova, Italy. |
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| Abstract: | Starting from (3S,4R,1'S)-3-amino-2-oxo-1-[1'-(4-methoxyphenylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a beta-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirmed by molecular dynamics (MD) simulations. |
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