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An improved synthesis of 2-oxa-7-azaspiro[3,5]nonane and analogs as novel reagents in medicinal chemistry |
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| Authors: | Ruo XuMichael Czarniecki Jos de ManJianping Pan Li QiangYuriko Root Shihong YingJing Su Xijun SunYuping Zhang Tao YuYang Zhang Tao HuShu-Hui Chen |
| Institution: | a Department of Chemical Research, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States b Department of Medicinal Chemistry, Merck Research Laboratory, PO Box 20, 5349 BH, Oss, The Netherlands c Wuxi AppTec Co., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China |
| Abstract: | A detailed synthesis of novel spirocyclic oxetane analogs is described for the first time. |
| Keywords: | Spirocyclic oxetane 2-Oxa-7-azaspiro[3 5]nonane 2-Oxa-6-azaspiro[3 5]nonane 2-Oxa-6-azaspiro[3 4]octane |
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