Design and divergent synthesis of aza nucleosides from a chiral imino sugar |
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Authors: | Martínez-Montero Saúl Fernández Susana Sanghvi Yogesh S Chattopadhyaya Jyoti Ganesan Muthupandian Ramesh Namakkal G Gotor Vicente Ferrero Miguel |
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Institution: | Departamento de Qu??mica Orgánica e Inorgánica and Instituto Universitario de Biotecnolog??a de Asturias, Universidad de Oviedo, 33006 Oviedo (Asturias), Spain. |
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Abstract: | Several novel nucleoside analogues as potential inhibitors of glycosidases and purine nucleoside phosphorylase (PNP) have been synthesized via selective coupling of an appropriate nucleobase at different positions of an orthogonally protected imino sugar as a common precursor. This synthetic strategy offers a straightforward protocol for the assembly of imino sugar containing nucleosides, establishing a new repertoire of molecules as potential therapeutics. |
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