Two new antitumor diterpenes from Pinus sylvestris |
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Authors: | Qiang Wang Zhang Rong Jie Teng Yoshihisa Takaishi Hong Quan Duan |
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Affiliation: | a School of Pharmaceutical Sciences, Basic Medical Research Center of Tianjin, Tianjin Medical University, Tianjin 300070, China;b Henan Analysis and Testing Center, Zhengzhou 450002, China;c Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan |
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Abstract: | Two new diterpenes,15-ethyl- 18-methyl pinifolate (1)and 18-hydroxy-labda-8(17),13E-dien-15-acetate (2),were isolated fromthe needles of Pinus sylvestris.Their structures were elucidated by spectroscopic methods,including 2D-NMR spectra.Compound1 exhibited the significant eytotoxic activity against the human carcinoma cell lines Hela,SK-N-SH and BEL-7402 in vitro. |
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Keywords: | Pinus sylvestris P.E.extract Diterpenes Cytotoxic activity |
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