Two new antitumor diterpenes from Pinus sylvestris |
| |
| Authors: | Qiang Wang Zhang Rong Jie Teng Yoshihisa Takaishi Hong Quan Duan |
| |
| Institution: | a School of Pharmaceutical Sciences, Basic Medical Research Center of Tianjin, Tianjin Medical University, Tianjin 300070, China;b Henan Analysis and Testing Center, Zhengzhou 450002, China;c Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan |
| |
| Abstract: | Two new diterpenes,15-ethyl- 18-methyl pinifolate (1)and 18-hydroxy-labda-8(17),13E-dien-15-acetate (2),were isolated fromthe needles of Pinus sylvestris.Their structures were elucidated by spectroscopic methods,including 2D-NMR spectra.Compound1 exhibited the significant eytotoxic activity against the human carcinoma cell lines Hela,SK-N-SH and BEL-7402 in vitro. |
| |
| Keywords: | Pinus sylvestris P E extract Diterpenes Cytotoxic activity |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
|
