| 含吡啶环的[1,3,4]噁二唑类化合物的合成及表征 |
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| 引用本文： | 李志芬,张敏,崔利英,陆东亮,黄培刚,张军.含吡啶环的[1,3,4]噁二唑类化合物的合成及表征[J].有机化学,2008,28(3):476-478. |
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| 作者姓名： | 李志芬 张敏 崔利英 陆东亮 黄培刚 张军 |
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| 作者单位： | 苏州大学化学化工学院江苏省有机合成重点实验室,苏州215123 |
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| 摘 要： | 2,6-二甲基吡啶-3,5-二甲酸二乙酯在乙醇中与水合肼反应生成5-甲酰肼基-2,6-二甲基吡啶甲酸乙酯和2,6-二甲基吡啶-3,5-双酰肼, 使其与取代的苯甲醛反应, 得到相应的腙, 最后在N-溴代丁二酰亚胺(NBS)作用下成环. 化合物的结构分别通过了1H NMR, IR, MS, 元素分析确证.
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| 关 键 词： | 吡啶 酰肼 酰腙 NBS [1 3 4]噁二唑 |
| 收稿时间： | 2006-10-08 |
| 修稿时间： | 2007-08-10 |
Synthesis and Structural Characterization of 1,3,4-Oxadiazoles Bearing Pyridine Ring |
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| ZENG Run-Sheng,SHI Gui-Bin,JIA Ai-Quan,AN Li-Tao,ZOU Jian-Ping.Synthesis and Structural Characterization of 1,3,4-Oxadiazoles Bearing Pyridine Ring[J].Chinese Journal of Organic Chemistry,2008,28(3):476-478. |
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| Authors: | ZENG Run-Sheng SHI Gui-Bin JIA Ai-Quan AN Li-Tao ZOU Jian-Ping |
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| Institution: | (Department of Chemistry, Shanghai University, Shanghai 200444)(The Coal Factory of Bailipo, Panzhihua 617005) |
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| Abstract: | ,6-Dimethyl-5-ethoxycarbonylpyridine-3-hydrazide and 2,6-dimethylpyridine-3,5-dihydrazide were synthesized by the reaction of diethyl 2,6-dimethylpyridine-3,5-dicarboxylate with hydrazine hydrate in ethanol, then, reacted with substituted benzaldehyde to obtain N-acylhydrazones. At last, a series of new target compounds were formed in the presence of N-bromosuccinimide, which were characterized by 1H NMR, IR, MS spectra and elemental analyses. |
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| Keywords: | pyridine hydrazide N-acylhydrazone N-bromosuccinimide 1 3 4-oxadiazole |
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