Stereolabile chiral compounds: analysis by dynamic chromatography and stopped-flow methods |
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Authors: | Wolf Christian |
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Institution: | Department of Chemistry, Georgetown University, Washington DC 20057, USA. cw27@georgetown.edu |
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Abstract: | Enantiomerization and diastereomerization reactions of chiral compounds play a major role in all aspects of chemistry spanning a wide bridge from drug development to supramolecular chemistry. Traditionally, these reactions are studied by variable-temperature NMR spectroscopy and chiroptical methods such as polarimetry. However, powerful complimentary methods based on chromatography and electrophoresis have been developed and applied to a variety of stereolabile chiral compounds. This tutorial review explains the principles, applications, and limitations of dynamic chromatography and chromatographic and electrophoretic stopped-flow analysis for the investigation of isomerization reactions of chiral compounds. |
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