Biosynthesis of beta-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. |
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| Authors: | F Ikegami S Itagaki T Ishikawa G Ongena Y H Kuo F Lambein I Murakoshi |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Chiba University, Japan. |
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| Abstract: | beta-(Isoxazolin-5-on-2-yl)alanine (BIA), a biosynthetic precursor of the neurotoxic amino acid beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the biosynthesis of BIA are described. |
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