A luminescent sensor for tyrosine phosphorylation |
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Authors: | Tremblay Matthew S Lee Minhee Sames Dalibor |
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Institution: | Department of Chemistry, Columbia University, New York, New York 10027, USA. |
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Abstract: | We have developed a luminogenic probe for tyrosine phosphorylation based on a short peptide sequence containing an iminodiacetate moiety near the site of phosphorylation. In response to kinase activity, the probe provides a strong luminescence enhancement, resulting from the increased ability of the probe to bind and sensitize Tb3+ and Eu3+ ions upon phosphorylation. |
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