Selective One-Pot Conversion of Carboxylic Acids into Alcohols |
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Authors: | Kokotos George Noula Caterina |
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Institution: | Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece. |
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Abstract: | Carboxylic acids are converted into alcohols by chemoselective reduction of their corresponding fluorides with sodium borohydride and dropwise addition of methanol. The method is general and mild and displays a high level of functional group compatibility. N-Protected amino and peptide alcohols, bearing varieties of protecting groups, are prepared in the same way from their corresponding amino acids and peptides without racemization. |
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