A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide |
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| Authors: | Moss Jason A Lillo Antonietta Kim Young Soo Gao Changshou Ditzel Henrik Janda Kim D |
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| Institution: | Departments of Chemistry and Immunology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | The internalization mechanism of a cell-penetrating peptide has been explored through combinatorial selection of a phage-displayed peptide dimer library, chemical synthesis, and biophysical characterization. Both energy-dependent and energy-independent modes for peptide uptake by the target mammalian cells were observed, suggesting a role for higher-order structure in modulating the action of this novel cell-penetrating peptide. |
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