Stereocontrolled formal synthesis of (+/-)-platensimycin |
| |
Authors: | Matsuo Jun-ichi Takeuchi Kosuke Ishibashi Hiroyuki |
| |
Institution: | Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. jimatsuo@p.kanazawa-u.ac.jp |
| |
Abstract: | The caged structure of platensimycin, known as Nicolaou's key intermediate for total synthesis of platensimycin, was synthesized stereoselectively by using the following key steps: (i) diastereoselective Diels-Alder reaction between gamma-benzoyloxy enone and tert-butyldimethylsiloxydiene, (ii) formation of a dihydropyran ring by intramolecular catalytic oxypalladation, and (iii) transannular radical cyclization of monothioacetal with tributyltin hydride and AIBN. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|