| 二维大环网状结构的双(三环已基锡)二元酸酯的合成、结构及生物活性 |
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| 引用本文： | 邝代治,朱小明,冯泳兰,张复兴,庾江喜,蒋伍玖,谭宇星,张志坚.二维大环网状结构的双(三环已基锡)二元酸酯的合成、结构及生物活性[J].无机化学学报,2013,29(18). |
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| 作者姓名： | 邝代治 朱小明 冯泳兰 张复兴 庾江喜 蒋伍玖 谭宇星 张志坚 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院生命科学与环境学院, 衡阳 421008 |
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| 基金项目： | 湖南省自然科学基金(13JJ3112)和科技计划(2014NK3086,2014FJ3060)项目,功能金属有机材料湖南省普通高校重点实验室开放基金资助项目(13K105,14K014,13K01-05,GN14K01),湖南省重点学科基金和湖南省高校科技创新团队支持计划资助项目,衡阳师范学院科学基金(No.12C45),湖南省教育厅基金项目(No.15C0199,15C0200,14C0171,14C0168)资助。 |
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| 摘 要： | 三环己基氢氧化锡分别与辛二酸和壬二酸进行甲醇溶剂热反应,合成了2个双(三环已基锡)二元酸酯(CH2)n(CO2SnCy3)2(n:6(1),7(2)],并用IR、1H和13C NMR、元素分析和X射线单晶衍射表征结构。化合物1、2均属单斜晶系,空间群分别为P21/n和P21/c,在化合物的晶体中,1通过Sn-O共价键,2通过Sn-O和Sn…O弱作用,分别形成了四锡核30元(1)和32元(2)二维大环网状结构。化合物1、2对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460均具有良好的体外抑制活性,对S. Aureus、B. Subtilis、E. Coli和S. Typhi具有选择性的抑菌作用。
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| 关 键 词： | 双[三环己基锡基锡]二元羧酸酯 大环化合物 晶体结构 生物活性 |
Syntheses, Crystal Structures and Biological Activities of Bis(tricyclohexyltin)dicarboxylates with Macrocyclic Building 2D Network |
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| KUANG Dai-Zhi,ZHU Xiao-Ming,FENG Yong-Lan,ZHANG Fu-Xing,YU Jiang-Xi,JIANG Wu-Jiu,TAN Yu-Xing and ZHANG Zhi-Jian.Syntheses, Crystal Structures and Biological Activities of Bis(tricyclohexyltin)dicarboxylates with Macrocyclic Building 2D Network[J].Chinese Journal of Inorganic Chemistry,2013,29(18). |
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| Authors: | KUANG Dai-Zhi ZHU Xiao-Ming FENG Yong-Lan ZHANG Fu-Xing YU Jiang-Xi JIANG Wu-Jiu TAN Yu-Xing and ZHANG Zhi-Jian |
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| Institution: | College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China,College of Chemistry and Material Science, Hengyang Normal University, Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China and College of Life Science and Environment, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Two bis(tricyclohexyltin)dicarboxylate(CH2)n(CO2SnCy3)2(n:6(1), 7(2)] have been synthesized by the reaction of suberic acid and azelaic acid with tricyclohexyltin hydroxide, respectively. The structures of the products were confirmed by IR, 1H and 13C NMR, elemental analysis and X-ray diffraction. The complexes 1 and 2 belong to monoclinic, space group P21/n and P21/c. A 2D network structure was formed by 30-membered or 32-membered macrocyclic tetratin species, which has been alternately connected through the Sn-O covalent bond or the Sn-O covalent bond and Sn...O weak interaction, respectively. The tests showed the two complexes displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460 and has selective antibacterial property for S. Aureus, B. Subtilis, E. Coli and S. Typhi. |
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| Keywords: | bis(tricyclohexyltin)dicarboxylate macrocycle compounds crystal structure biological activity |
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