Chemoenzymatic synthesis of neuraminic acid containing C-glycoside polymers |
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| Authors: | Wang Qun Dordick Jonathan S Linhardt Robert J |
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| Affiliation: | Division of Medicinal and Natural Products Chemistry and Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA. |
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| Abstract: | [structure: see text] Two neuraminic acid-based, C-glycoside polymers were synthesized. Preliminary studies on one of these polymers showed potent neuraminidase inhibitory activity, suggesting potential utility as an antipathogenic surface coating for the preparation of antimicrobial biomaterials. |
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