Synthesis of novel imidazo[1,2-a]pyridines with potent activity against herpesviruses |
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Authors: | Gudmundsson Kristjan S Johns Brian A |
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Affiliation: | Department of Medicinal Chemistry, GlaxoSmithKline Research & Development, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina 27709-3398, USA. kristjan.s.gudmundsson@gsk.com |
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Abstract: | [reaction: see text] Synthesis of a novel imidazopyridine with potent activity against herpes simplex viruses is presented. Several synthetic approaches that describe the introduction of a C-3 pyrimidine substituent on the imidazopyridine core via construction of the pyrimidine or Stille coupling are outlined. Methodology for efficient installation of C-8 amine substituents was developed. The outlined strategies provide a high-yielding, scalable route that is amenable to rapid analogue synthesis. |
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