d‐Secoestrone derivatives. VI. 17β‐Benzyl‐17α‐hydroxy‐3‐methoxyestra‐1,3,5(10)‐trien‐16‐one |
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| Authors: | Slobodanka Stankovi&#x ,Du&#x an Lazar,Ljubica Medi&#x ‐Mija
evi&#x ,Katarina Penov‐Ga&#x i,Marija Saka
,Silvana Andri&#x ,Bruvo Milenko |
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| Affiliation: | Slobodanka Stanković,Dušan Lazar,Ljubica Medić‐Mijačević,Katarina Penov‐Gaši,Marija Sakač,Silvana Andrić,Bruvo Milenko |
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| Abstract: | The title molecule, C26H30O3, shows a novel chemical rearrangement of the substituents at position 17, i.e. an α‐orientation of the hydroxy group and a β‐orientation of the bulky benzyl moiety. The packing arrangement consists of coils formed by O2?O3 hydrogen bonds along the c axis. The compound shows complete loss of oestrogenic activity, and neither does it exhibit an antagonistic effect. |
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