Steroid 19,B‐dinor‐8,10‐iso‐analogues

The Birch reduction of 3‐methoxy‐B‐nor‐8‐isoestra‐1,3,5(10)‐trienes followed by acid hydro­lysis produces steroid androgen 19,B‐dinor‐8,10‐iso‐analogues. By means of X‐ray analysis and correlation NMR spectroscopy of 16,16‐di­methyl‐D‐homo‐19,B‐dinor‐8‐isotestosterone, C₂₀H₃₀O₂, it is demonstrated that the main conformations in the crystal and in solution for two 19,B‐dinor‐8,10‐iso‐analogues are, in general, the same.