| PMBP缩氨基酚的合成、晶体结构及抑菌活性 |
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| 引用本文： | 王瑾玲,张姝明,张欣,缪方明.PMBP缩氨基酚的合成、晶体结构及抑菌活性[J].化学学报,2003,61(7):1071-1076. |
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| 作者姓名： | 王瑾玲 张姝明 张欣 缪方明 |
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| 作者单位： | 1. 天津师范大学化学与生命科学学院,天津,300074
2. 天津师范大学化学与生命科学学院,天津,300074;河北工业大学化工学院,天津,300130 |
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| 基金项目： | 天津市自然科学基金(No.003601711)，天津市高等学校科技发展基金(No.01-20601) |
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| 摘 要： | 利用1－苯基－3－甲基－4－苯甲酰基－5－吡唑啉酮（PMBP）与邻、间、对氨 基酚合成了三种PMBP缩氨基酚Schiff碱，并进行了结构表征。PMBP缩邻氨基酚的X 射线衍射分析测定结果表明，该缩合反应是通过质子转移形式，形成了烯胺酮式结 构。抑菌活性测定结果表明它们对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆 菌有较强的抑制作用。
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| 关 键 词： | 氨基酚 P 晶体结构 吡唑酮 P 席夫碱 结构表征 X射线衍射分析 抑菌性 |
| 修稿时间： | 2002年10月29 |
Synthesis, Crystal Structure and Bacteriostatic Activities of Compounds Derived from PMBP and Aminophenol |
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| WANG,Jin-Ling ZHANG,Shu-Ming ZHANG,Xin MIAO,Fang-Ming.Synthesis, Crystal Structure and Bacteriostatic Activities of Compounds Derived from PMBP and Aminophenol[J].Acta Chimica Sinica,2003,61(7):1071-1076. |
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| Authors: | WANG Jin-Ling ZHANG Shu-Ming ZHANG Xin MIAO Fang-Ming |
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| Institution: | College of Chemistry and Life, Tianjin Normal University.Tianjin (300074) |
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| Abstract: | Three new compounds derived from l-phenyl-3-methyl-4-benzoyl-pyrazolin-5-one with o-aminophenol (A), m-aminophenol (B) and p-aminophenol (C) have been synthesized. Their structures are characterized by IR, UV and 1H NMR. X-ray structure determination of the compound A shows that it is a neutral tridentate ligand in enamineketo form. The bacteriostatic activities of the three compounds have been determined by paper disc method. The tests indicated that they have good bacteriostatic activities against Escherichia cocli and Staphyococcus aureus. It provides basis for the determination of the antibacterial activity of their complexes. |
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| Keywords: | Schiff base synthesis characterization crystal structure bacteriostatic activities |
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