| 盐酸黄连碱的全合成 |
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| 引用本文： | 陈帅,童元峰,吴松. 盐酸黄连碱的全合成[J]. 合成化学, 2009, 17(4) |
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| 作者姓名： | 陈帅 童元峰 吴松 |
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| 作者单位： | 中国医学科学院,北京协和医学院,药物研究所,北京,100050;中国医学科学院,北京协和医学院,药物研究所,北京,100050;中国医学科学院,北京协和医学院,药物研究所,北京,100050 |
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| 摘 要： | 以2,3-二甲氧基苯甲醛为起始原料,经脱甲基、环和、缩和闭环等5步反应合成了盐酸黄连碱,总收率9.9%,其结构经1H NMR和MS表征.
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| 关 键 词： | 苯甲醛 黄连碱 全合成 药物合成 |
Total Synthesis of Coptisine Hydrochloride |
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| CHEN Shuai,TONG YUAN-feng,WU Song. Total Synthesis of Coptisine Hydrochloride[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(4) |
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| Authors: | CHEN Shuai TONG YUAN-feng WU Song |
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| Affiliation: | Institute of Materia Medica;Chinese Academy of Medical Sciences & Peking Union Medical College;Beijing 100050;China |
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| Abstract: | Coptisine hydrochloride in overall yield of 9.9% was synthesized from 2,3-dimethoxybenzaldehyde by a five-step reaction of demethylation,cyclization,condensation,ring-closing reaction and so on.The structure was characterized by 1H NMR and MS. |
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| Keywords: | benzaldehyde coptisine total synthesis drug synthesis |
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