Highly enantioselective conjugate addition of thiols using mild scandium triflate catalysis |
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| Authors: | Abe Aki M M Sauerland Sami J K Koskinen Ari M P |
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| Institution: | Laboratory of Organic Chemistry, Helsinki University of Technology, P.O.B. 6100, FI-02015 TKK, Finland. |
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| Abstract: | A Sc complex of (4S,5S)-diphenyl PYBOX 1 was found to serve as a catalyst for the asymmetric conjugate addition reactions between various thiols and 3-crotonoyl-2-oxazolidinone, affording the corresponding adducts in good yields and high enantioselectivies (up to 92% ee). A new improved method for making (4S,5S)-diphenyl PYBOX is presented. |
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