Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules |
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Affiliation: | 1. Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India;2. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia |
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Abstract: | An expedient regioselectivesynthesis of novel mono, C2-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding steps starting from dimedone, while the symmetrical aliphatic and aryl bis-azides were derived from appropriate dibromides in the presence of sodium azide in dry DMF. The synthesized mono and C2-symmetric bis-macromolecules have been elucidated by 1H, 13C, elemental and mass spectroscopic analysis. The antioxidant activity of synthesized compounds has also been investigated. |
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Keywords: | Acridinedione 1,2,3-Triazole Macromolecules Azide Click Chemistry reaction Antioxidant activity |
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