|
|||||
|
|
Enantioselective syntheses of (R)-3-phenyl GABA, (R)-baclofen and 4-arylpyrrolidin-2-ones |
|
| Authors: | Nicole Langlois Nathalie Dahuron Hai-Shan Wang |
| Institution: | Institut de Chimie des Substances Naturelles, C.N.R.S., 91198, Gif-sur-Yvette, France |
| Abstract: | Enantioselective synthesis of (R)-4-amino-3-phenylbutyric acid and (R)-baclofen has been achieved through a diastereoselective conjugate addition of cyanide to enantiomericaly pure 2-(2-arylethenyl)oxazolines, followed by chemoselective reduction into cyclic amidines. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |